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. 2004 Aug 4;1689(3):175-8.
doi: 10.1016/j.bbadis.2004.05.005.

Interaction of ACE2 and integrin beta1 in failing human heart

Qishan Lin  1 , Rebecca S Keller, Barbara Weaver, Lawrence S Zisman
Affiliations
Free article

Interaction of ACE2 and integrin beta1 in failing human heart

Qishan Lin et al. Biochim Biophys Acta. .
Free article

Abstract

ACE2 purified from failing human heart was found to form a complex with integrin beta1 by immunoprecipitation, Western blotting, activity assay, and ESI tandem mass spectroscopy. The ACE2/integrin complex showed a Km of 6.8 microM and a Vmax of 2.13 pmol/min/microl purified enzyme. Activity was optimal at pH 7.5 with Ang II substrate.

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