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Comparative Study
. 2004 Jul;167(3):1275-80.
doi: 10.1534/genetics.104.027037.

The Mod(mdg4) component of the Su(Hw) insulator inserted in the P transposon can repress its mobility in Drosophila melanogaster

Marina Karakozova  1 , Ekaterina Savitskaya, Larisa Melnikova, Aleksandr Parshikov, Pavel Georgiev
Affiliations
Comparative Study

The Mod(mdg4) component of the Su(Hw) insulator inserted in the P transposon can repress its mobility in Drosophila melanogaster

Marina Karakozova et al. Genetics. 2004 Jul.

Abstract

Transposable element P of Drosophila melanogaster is one of the best-characterized eukaryotic transposons. Successful transposition requires the interaction between transposase complexes at both termini of the P element. Here we found that insertion of one or two copies of the Su(Hw) insulator in the P transposon reduces the frequency of its transposition. Inactivation of a Mod(mdg4) component of the Su(Hw) insulator suppresses the insulator effect. Thus, the Su(Hw) insulator can modulate interactions between transposase complexes bound to the ends of the P transposon in germ cells.

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