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Comment
. 2004 Aug 2;200(3):273-6.
doi: 10.1084/jem.20040812. Epub 2004 Jul 26.

Suppressor T cells in human diseases

Clare Baecher-Allan  1 , David A Hafler
Affiliations
Comment

Suppressor T cells in human diseases

Clare Baecher-Allan et al. J Exp Med. .

Abstract

Although central and peripheral tolerance are important for the regulation of human immune responses to self- and microbial antigens, an important role of suppressor CD4(+) CD25(+) T cells is suggested from the recent investigations of human autoimmune diseases and HIV. These new data provide increasing evidence that altered function of CD4(+) CD25(+) T cells may be an important factor in a wide range of human inflammatory and infectious diseases.

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