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. 2004 Aug 7;2(15):2161-4.
doi: 10.1039/b407773c. Epub 2004 Jun 30.

Palladium--phosphinous acid-catalyzed Sonogashira cross-coupling reactions in water

Christian Wolf  1 , Rachel Lerebours
Affiliations

Palladium--phosphinous acid-catalyzed Sonogashira cross-coupling reactions in water

Christian Wolf et al. Org Biomol Chem. .

Abstract

A palladium--phosphinous acid-catalyzed Sonogashira cross-coupling reaction that proceeds in water under air atmosphere in the absence of organic co-solvents has been developed. Disubstituted alkynes have been prepared in up to 91% yield by POPd-catalyzed coupling of various aryl halides including chlorides in the presence of tetrabutylammonium bromide and pyrrolidine or NaOH.

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