Insulin-cancer relationships: possible dietary implication

Abstract

Insulin is a major anabolic hormone in mammals and its involvement in malignancies is well documented. An attempt is made to classify experimental and human cancers into four groups, according to the way the tumors are affected by, or interact with, insulin. Such an approach provides a better understanding of the dietary effects on tumorigenesis. Since human cancers are of the insulin-producing/secreting or insulin-dependent types, it is suggested that screening of individuals for blood insulin level and reducing the insulin status by dietary means may lead to a decreased risk of cancer. Anti-insulin drugs may be useful as supplements to therapeutic treatment.