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. 2004 Aug 5;6(16):2729-31.
doi: 10.1021/ol049074w.

Stereocontrolled total synthesis of potent immunosuppressant FR901483

Toshiyuki Kan  1 , Teppei Fujimoto, Shigeru Ieda, Yusuke Asoh, Haruka Kitaoka, Tohru Fukuyama
Affiliations

Stereocontrolled total synthesis of potent immunosuppressant FR901483

Toshiyuki Kan et al. Org Lett. .

Abstract

A total synthesis of the potent immunosuppressant FR901483 (1) has been accomplished. The key feature of our convergent synthesis is the stereoselective incorporation of the p-methoxybenzyl and methylamino groups within the core moiety 10. Tricycle 10 was itself constructed by an intramolecular aldol reaction of the symmetrical keto-aldehyde 7. [Structure: see text]

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