Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Aug 4;126(30):9168-9.
doi: 10.1021/ja0492539.

Doxorubicin accumulation in individually electrophoresed organelles

Adrian B Anderson  1 , Guohua Xiong, Edgar A Arriaga
Affiliations

Doxorubicin accumulation in individually electrophoresed organelles

Adrian B Anderson et al. J Am Chem Soc. .

Abstract

We report the doxorubicin content in individual organelles following their capillary electrophoretic separation and illustrate that chemical accumulation at the subcellular level is highly heterogeneous. In individual mitochondria from cultured human leukemia cells DOX amount is around 50 zmol, 2 orders of magnitude higher than expected from diffusion during drug treatment, and spans 2 orders of magnitude.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources