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Clinical Trial
. 2004 Jun;50(3):127-32.
doi: 10.1159/000077886.

Gemcitabine combined with infusional 5-fluorouracil and high-dose leucovorin for the treatment of advanced carcinoma of the pancreas

Ilhan Oztop  1 , Ugur Yilmaz, Tugba Yavuzsen, Arzu Yaren, Oktay Tarhan, Ozgul Sagol, Ahmet Coker, Mehmet Alakavuklar
Affiliations
Clinical Trial

Gemcitabine combined with infusional 5-fluorouracil and high-dose leucovorin for the treatment of advanced carcinoma of the pancreas

Ilhan Oztop et al. Chemotherapy. 2004 Jun.

Abstract

Background: 5-Fluorouracil (5-FU) and gemcitabine are the major active drugs in the treatment of pancreatic cancer.

Methods: Twenty-two patients with advanced pancreas cancer were treated with a new chemotherapy regimen consisting of infusional 5-FU and high-dose leucovorin with gemcitabine (GEMFUFOL).

Results: A total of 200 cycles of chemotherapy were administered. The response rate was 27.3%, all responses being partial. The median survival time and 1-year survival rate were, respectively, 13 months and 60.4%. The toxicity was very low and severe hematological toxicity was exceptional.

Conclusion: The GEMFUFOL regimen can be an active regimen for the treatment of advanced pancreatic cancer and has a low toxicity.

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