Inhibitory effect of manganese on contraction of isolated rat aorta
Affiliations
- PMID: 15282946
Item in Clipboard
Inhibitory effect of manganese on contraction of isolated rat aorta
Indian J Exp Biol.
2004 Feb.
Abstract
The effects of MnCl2 on vascular smooth muscle contraction induced by noradrenaline (NA) and KCl were investigated. Rings segments from rat aorta were isolated and changes in isometric tension recorded. MnCl2 (10 microM and 1 mM) significantly attenuated the contractile responses to NA and KCI. There were also reductions in the contractile responses to CaCl2 in NA- and KCl-stimulated rings, after pretreatment with MnCl2. The magnitude of the phasic contraction to NA was significantly reduced in presence of MnCl2. The results suggest that MnCl2 inhibits vascular smooth muscle contraction by influencing a Ca2+-mediated mechanism.
Similar articles
-
A voltage-dependent noradrenaline-sensitive intracellular calcium store in smooth muscle cells of the guinea-pig aorta.Can J Physiol Pharmacol. 1997 Sep;75(9):1129-37. Can J Physiol Pharmacol. 1997. PMID: 9365825
-
Etomidate attenuates phenylephrine-induced contraction in isolated rat aorta.Can J Anaesth. 2005 Nov;52(9):927-34. doi: 10.1007/BF03022053. Can J Anaesth. 2005. PMID: 16251557
-
Inhibition of smooth muscle cell calcium mobilization and aortic ring contraction by lactone vastatins.J Hypertens. 1996 Jan;14(1):115-21. J Hypertens. 1996. PMID: 12013483
-
Metamizol acts as an ATP sensitive potassium channel opener to inhibit the contracting response induced by angiotensin II but not to norepinephrine in rat thoracic aorta smooth muscle.Vascul Pharmacol. 2005 Aug;43(2):120-7. doi: 10.1016/j.vph.2005.05.003. Vascul Pharmacol. 2005. PMID: 15958287
-
Halothane decreases calcium sensitivity of rat aortic smooth muscle.Can J Anaesth. 1999 Dec;46(12):1164-71. doi: 10.1007/BF03015527. Can J Anaesth. 1999. PMID: 10608212
MeSH terms
Substances
LinkOut - more resources
Miscellaneous