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Comparative Study
. 2004 Jun;45(6):481-5.

Comparison of medetomidine-ketamine and dexmedetomidine-ketamine anesthesia in golden-headed lion tamarins

André L Selmi  1 , Guilherme M Mendes, Juliana P Figueiredo, Glenda R Barbudo-Selmi, Bruno T Lins
Affiliations
Comparative Study

Comparison of medetomidine-ketamine and dexmedetomidine-ketamine anesthesia in golden-headed lion tamarins

André L Selmi et al. Can Vet J. 2004 Jun.

Abstract
in English, French

The cardiovascular, respiratory, and anesthetic effects of medetomidine-ketamine (20 microg/kg bodyweight [BW] and 10 mg/kg BW) (MK group) or dexmedetomidine-ketamine (10 microg/kg BW and 10 mg/kg BW) (DK group) were studied in golden-headed lion tamarins. Heart rate decreased after administration of both combinations; this reduction was statistically greater in the DK group than in the MK group after 15 and 45 minutes. Systolic arterial pressure decreased in a similar way in both groups, except at 15 minutes, when systolic arterial pressure was significantly lower in the DK group. Diastolic arterial pressure, mean arterial pressure, respiratory rate, and rectal temperature were progressively reduced in all groups. Sedation time was significantly shorter and anesthesia time was significantly longer in the DK group compared with MK group. Anesthetic quality and analgesia scores were significantly greater at 5 and 15 minutes in the DK group compared with the MK group. The administration of dexmedetomidine-ketamine is as safe and effective as the administration of medetomidine-ketamine in tamarins.

Résumé — Comparaison des anesthésies à la médétomidine-kétamine et à la dexmédétomidine-kétamine chez le tamarin à tête dorée. Les effets cardiovasculaires, respiratoires et anesthésiques de la médétomidine-kétamine (20 μg/kg de poids corporel (PC) et 10 mg/kg PC) (groupe MK) ou de la dexmédétomidine — kétamine (10 μg/kg/PC et 10 mg/kg PC) (groupe DK) ont été étudiés chez le tamarin à tête dorée. La fréquence cardiaque a diminué après l’administration des 2 associations; cette diminution était statistiquement plus importante chez le groupe DK que chez le groupe MK après 15 et 45 minutes. La pression artérielle systolique a diminué de façon similaire chez les 2 groupes, sauf à 15 minutes, alors que la pression artérielle systolique était significativement plus basse chez le groupe DK. La pression artérielle diastolique, la pression artérielle moyenne, la fréquence respiratoire et la température rectale diminuaient progressivement chez tous les groupes. Le temps de sédation était significativement plus court, le temps d’anesthésie était significativement plus long chez le groupe DK comparé au groupe MK. La qualité de l’anesthésie et les cotations analgésiques étaient significativement plus grandes à 5 et 15 minutes chez le groupe DK en comparaison avec le groupe MK. L’administration de dexmétomidinekétamine est aussi sécuritaire et efficace que l’administration de médétomidine-kétamine chez le tamarin.

(Traduit par Docteur André Blouin)

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Figures

Figure 1
Figure 1
Mean sedation and muscle relaxation scores in golden-headed lion tamarins undergoing medetomidine/ketamine (MK) or dexmedetomidine/ketamine (DK) anesthesia. Mean values between groups with different alphabetic superscripts are significantly different (P < 0.05).
Figure 2
Figure 2
Mean analgesia and auditory response scores in golden-headed lion tamarins undergoing medetomidine/ketamine (MK) or dexmedetomidine/ketamine (DK) anesthesia. Mean values between groups with different alphabetic superscripts are significantly different (P < 0.05).
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