Fetal fibronectin and bacterial vaginosis are associated with preterm birth in women who are symptomatic for preterm labor

Abstract

Objective: The purpose of this study was to codify the relationship between bacterial vaginosis/fetal fibronectin and preterm labor/birth.

Study design: In this prospective study, 185 women who were symptomatic for preterm labor were assessed for bacterial vaginosis and fetal fibronectin.

Results: These women comprised 4 groups: group A (n=23 women; +bacterial vaginosis/+fetal fibronectin); group B (n=31 women; -bacterial vaginosis/+fetal fibronectin); group C (n=47 women; +bacterial vaginosis/-fetal fibronectin); and group D (n=84 women; -bacterial vaginosis/-fetal fibronectin). The time interval from gestational age at testing until delivery was significantly shorter for groups A and B versus groups C and D (P < or =.05 and P <.001, respectively). Similarly, delivery at <32 weeks of gestation was increased in group B (26%) compared with groups A (9%), C (2%), and D (5%; P <.009; odds ratio, 165.90; 95% CI, 30.02, 916.08).

Conclusion: Women who are symptomatic for preterm labor should be considered for fetal fibronectin and bacterial vaginosis testing.