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Review
. 2004 Aug;114(3):319-21.
doi: 10.1172/JCI22497.

Pulmonary fibrosis: thinking outside of the lung

Stavros Garantziotis  1 , Mark P Steele, David A Schwartz
Affiliations
Review

Pulmonary fibrosis: thinking outside of the lung

Stavros Garantziotis et al. J Clin Invest. 2004 Aug.

Abstract

Pulmonary fibrosis is a devastating condition that leads to progressive lung destruction and scarring. Previous mechanistic research has focused on the local fibroproliferative process in the lung. However, emerging evidence suggests that circulating cells of hematopoietic origin play a crucial role in the pathogenesis of this disease.

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Figures

Figure 1
Figure 1
Proposed mechanism for the pathogenesis of pulmonary fibrosis. The lung is naturally exposed to repetitive injury from a variety of exogenous and endogenous stimuli. Several local and systemic factors (e.g., fibroblasts, circulating fibrocytes, chemokines, growth factors, and clotting factors) contribute to tissue healing and functional recovery. Dysregulation of this intricate network through genetic predisposition, autoimmune conditions, or superimposed diseases can lead to aberrant wound healing with the result of pulmonary fibrosis. Alternatively, excessive injury to the lung may overwhelm even intact reparative mechanisms and lead to pulmonary fibrosis. The figure was adapted with permission from the New England Journal of Medicine (1).
See this image and copyright information in PMC

Comment on

References

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