Proton magnetic resonance imaging of diffusion of high- and low-molecular-weight contrast agents in opaque porous media saturated with water

Abstract

Besides their use in contrast-enhanced proton magnetic resonance imaging (MRI), contrast agents were found to be useful as tracer molecules. Since paramagnetic ions in water have the ability to reduce the T1 of protons around them, MRI can determine the locations of Mn2+ and Gd3+ of ppm concentration in water. In opaque porous media saturated with water, MRI revealed diffusional motions of three contrast agents: MnCl2 (molecular-weight [M.W.], 126), gadolinium-diethylene-triaminepenta acetic acid (Gd-DTPA) (M.W., 743) and albumin (Gd-DTPA) (M.W., 94,000) at a diffusional displacement ratio of 9:5:2. With the aid of these contrast agents, the transport of low- to high-molecular-weight molecules in opaque water media such as living bodies can be observed using MRI.