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. 2004 May;10(3):245-50.
doi: 10.1097/00054725-200405000-00011.

The pathogenicity of cytomegalovirus in inflammatory bowel disease: a systematic review and evidence-based recommendations for future research

Daniel W Hommes  1 , Gerben Sterringa, Sander J H van Deventer, Guido N J Tytgat, Jan Weel
Affiliations

The pathogenicity of cytomegalovirus in inflammatory bowel disease: a systematic review and evidence-based recommendations for future research

Daniel W Hommes et al. Inflamm Bowel Dis. 2004 May.

Abstract

During recent years, a clear association between complicated courses of ulcerative colitis and the presence of cytomegalovirus (CMV) has been established. The exact pathogenic role of CMV in these patients remains unclear despite a great number of published reports. Therefore, we undertook a systematic review to appraise critically all available evidence in the literature on the role of CMV during inflammatory bowel disease. We identified and analyzed more than 30 case reports and 9 case series. Based on these results, we propose a model for viral replication during inflammation and provide recommendations for future research.

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