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. 2004 Aug;89(8):4119-23.
doi: 10.1210/jc.2003-031882.

Presence of luteinizing hormone/human chorionic gonadotropin receptors in male breast tissues

Harold E Carlson  1 , Philip Kane, Z M Lei, X Li, C V Rao
Affiliations

Presence of luteinizing hormone/human chorionic gonadotropin receptors in male breast tissues

Harold E Carlson et al. J Clin Endocrinol Metab. 2004 Aug.

Abstract

Receptors for LH/human chorionic gonadotropin (hCG) have been found in a variety of nongonadal tissues including the female breast. Using in situ hybridization and immunohistochemistry, we demonstrated the presence of LH/hCG receptor mRNA and protein in normal male breast tissue obtained at autopsy (n = 4) and archival samples of benign gynecomastia (n = 14) and male breast carcinoma (n = 5). Although the function of these receptors remains to be determined, the findings suggest the possibility that LH and hCG may play a role in the pathogenesis of male breast disorders.

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