Comment
doi: 10.1016/j.cell.2004.07.018.
Gene targeting: attention to detail
Affiliations
- PMID: 15294152
- DOI: 10.1016/j.cell.2004.07.018
Item in Clipboard
Comment
Gene targeting: attention to detail
Cell.
.
Free article
Abstract
When it comes to silencing genes in mice, not all approaches are equal. An example published in this issue of Cell (Patrucco et al., 2004) suggests that caution should be used when validating potential drug targets by genetic disruption.
Comment on
-
PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects.Cell. 2004 Aug 6;118(3):375-87. doi: 10.1016/j.cell.2004.07.017. Cell. 2004. PMID: 15294162
Similar articles
-
The p85 regulatory subunit of PI3K mediates TSH-cAMP-PKA growth and survival signals.Oncogene. 2007 Mar 29;26(14):2039-47. doi: 10.1038/sj.onc.1210011. Epub 2006 Oct 9. Oncogene. 2007. PMID: 17043656
-
Cyclic AMP signaling as a mediator of vasculogenic mimicry in aggressive human melanoma cells in vitro.Cancer Res. 2009 Feb 1;69(3):802-9. doi: 10.1158/0008-5472.CAN-08-2391. Epub 2009 Jan 27. Cancer Res. 2009. PMID: 19176384
-
Stopping ras in its tracks.Cell. 2007 Jun 1;129(5):855-7. doi: 10.1016/j.cell.2007.05.031. Cell. 2007. PMID: 17540164
-
Identification of the macromolecular complex responsible for PI3Kgamma-dependent regulation of cAMP levels.Biochem Soc Trans. 2006 Aug;34(Pt 4):502-3. doi: 10.1042/BST0340502. Biochem Soc Trans. 2006. PMID: 16856844 Review.
-
Pleiotropic effects of phosphatidylinositol 3-kinase in monocyte cell regulation.Prog Nucleic Acid Res Mol Biol. 2006;81:51-95. doi: 10.1016/S0079-6603(06)81002-0. Prog Nucleic Acid Res Mol Biol. 2006. PMID: 16891169 Review. No abstract available.
Cited by
-
Involvement of phosphoinositide 3-kinase gamma in angiogenesis and healing of experimental myocardial infarction in mice.Circ Res. 2010 Mar 5;106(4):757-68. doi: 10.1161/CIRCRESAHA.109.207449. Epub 2010 Jan 7. Circ Res. 2010. PMID: 20056919 Free PMC article.
-
The p110 delta of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation.J Exp Med. 2008 Sep 29;205(10):2419-35. doi: 10.1084/jem.20072327. Epub 2008 Sep 22. J Exp Med. 2008. PMID: 18809712 Free PMC article.
-
Generation of N-ethyl-N-nitrosourea (ENU) diabetes models in mice demonstrates genotype-specific action of glucokinase activators.J Biol Chem. 2011 Nov 11;286(45):39560-72. doi: 10.1074/jbc.M111.269100. Epub 2011 Sep 15. J Biol Chem. 2011. PMID: 21921030 Free PMC article.
-
Molecular mechanisms of FasL-mediated 'reverse-signaling'.Mol Immunol. 2020 Nov;127:31-37. doi: 10.1016/j.molimm.2020.08.010. Epub 2020 Sep 7. Mol Immunol. 2020. PMID: 32905906 Free PMC article. Review.
-
Efficient and fast targeted production of murine models based on ENU mutagenesis.Mamm Genome. 2005 Jun;16(6):405-13. doi: 10.1007/s00335-004-3028-2. Mamm Genome. 2005. PMID: 16075367
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
