Comment on

• The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.

  Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, Palensky J, Wittes J. Pitt B, et al. N Engl J Med. 1999 Sep 2;341(10):709-17. doi: 10.1056/NEJM199909023411001. N Engl J Med. 1999. PMID: 10471456 Clinical Trial.
• Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study.

  Juurlink DN, Mamdani MM, Lee DS, Kopp A, Austin PC, Laupacis A, Redelmeier DA. Juurlink DN, et al. N Engl J Med. 2004 Aug 5;351(6):543-51. doi: 10.1056/NEJMoa040135. N Engl J Med. 2004. PMID: 15295047