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. 2004 Sep 1;190(5):971-4.
doi: 10.1086/423143. Epub 2004 Jul 23.

Correlation between Torque tenovirus infection and serum levels of eosinophil cationic protein in children hospitalized for acute respiratory diseases

Fabrizio Maggi  1 , Massimo Pifferi, Elena Tempestini, Letizia Lanini, Emanuela De Marco, Claudia Fornai, Elisabetta Andreoli, Silvano Presciuttini, Maria Linda Vatteroni, Mauro Pistello, Vincenzo Ragazzo, Pierantonio Macchia, Angelo Pietrobelli, Attilio Boner, Mauro Bendinelli
Affiliations

Correlation between Torque tenovirus infection and serum levels of eosinophil cationic protein in children hospitalized for acute respiratory diseases

Fabrizio Maggi et al. J Infect Dis. .

Abstract

Children with bronchopneumonia have considerably higher Torque tenovirus (TTV) loads than do children with milder acute respiratory diseases (ARDs). Moreover, in children with ARDs, high TTV loads correlate with low percentages of circulating CD3+ and CD4+ T cells and with elevated percentages of B cells, suggesting that TTV might be immunomodulatory. Here, we show that, in children with ARDs, the presence of TTV and TTV load correlate with concentrations of serum eosinophil cationic protein. The possible mechanisms whereby TTV infection might lead to augmented activity of eosinophils and the implications for pathogenesis are discussed.

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