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Review
. 2004 Aug;54(505):617-21.

Symptomatic diagnosis of prostate cancer in primary care: a structured review

William Hamilton  1 , Deborah Sharp
Affiliations
Review

Symptomatic diagnosis of prostate cancer in primary care: a structured review

William Hamilton et al. Br J Gen Pract. 2004 Aug.

Abstract

Background: Prostate cancer has the second highest cancer incidence and mortality in European men. Most prostate cancers are diagnosed after lower urinary tract symptoms (LUTS) are presented to primary care, but such symptoms more often have a benign cause. A general practitioner (GP) has to try and identify which of these patients have prostate cancer.

Aims: To review the presenting features of symptomatic prostate cancer.

Design of study: Structured review.

Method: We searched Medline from 1980 to 2003 for symptoms, signs, and investigations reported in prostate cancer. This list was then expanded by secondary searches of reference lists. We excluded studies on post-diagnostic topics, such as staging, treatment, and prognosis; studies on non-Western patients; and studies on investigations that are not available in primary care. A second cycle of exclusions removed studies whose results would not guide a GP in deciding whether a patient has prostate cancer.

Results: No studies from primary care compared prostate cancer patients directly with controls. Two secondary care studies had enough information to allow a comparison of symptoms in cases compared with controls. In these studies, symptoms were generally more prevalent in cases, but the differences were small. Screening and secondary care studies suggest that early prostate cancer is symptomless, and that locally advanced cancer has LUTS that are similar to those for benign prostatic hypertrophy.

Conclusion: There is a very weak evidence base for the primary care diagnosis of prostate cancer in men with lower urinary tract symptoms.

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References

    1. Sakr WA, Haas GP, Cassin BF, et al. The frequency of carcinoma and intraepithelial neoplasia of the prostate in young male patients. J Urol. 1993;150:379–385. - PubMed
    1. Murphy M, Johnston C, Whelan P, et al. Changing trends in prostatic cancer. BJU Int. 1999;83:786–791. - PubMed
    1. Tannock I. Eradication of a disease: how we cured symptomless prostate cancer. Lancet. 2002;359:1341–1342. - PubMed
    1. Quinn M, Babb P, Brock A, et al. Cancer trends in England and Wales 1950–1999. London: The Stationery Office; 2001. http://www.statistics.gov.uk/statbase/Product.asp?vlnk=4822 (accessed 22 Jun 2004)
    1. Horwich A, Waxman J, Abel P, et al. Tumours of the prostate. In: Souhami R, Tannock I, Hohenberger P, Horiot J-C, editors. The Oxford textbook of oncology. 2nd edn. Oxford: Oxford University Press; 2001. pp. 1939–1971.

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