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. 2004 Sep 1;10(17):2509-13.
doi: 10.3748/wjg.v10.i17.2509.

Effects of motilin and ursodeoxycholic acid on gastrointestinal myoelectric activity of different origins in fasted rats

Ping Fang  1 , Lei Dong, Jin-Yan Luo, Xiao-Long Wan, Ke-Xin Du, Ning-Li Chai
Affiliations

Effects of motilin and ursodeoxycholic acid on gastrointestinal myoelectric activity of different origins in fasted rats

Ping Fang et al. World J Gastroenterol. .

Abstract

Aim: To investigate gastrointestinal migrating myoelectric complex (MMC) and the effects of porcine motilin and ursodeoxycholic acid (UDCA) on MMC of gastrointestinal tract of different origins in fasted rats.

Methods: Three bipolar silver electrodes were chronically implanted on the antrum, duodenum and jejunum. Seven days later 24 experimental rats were divided into 2 groups. One group was injected with porcine motilin via sublingual vein at a dose of 20 microg/kg, the other group was perfused into stomach with UDCA. The gastrointestinal myoelectric activity was recorded 1 h before and 2 h after the test substance infusions into the rats.

Results: In all fasted rats a typical pattern of MMC was observed. Among the totally 68 activity fronts recorded in fasted rats under control, 67% started in duodenum, and 33% in antrum. MMC cycle duration and duration of phase III of antral origin were longer than those of duodenal origin. Administration of 20 microg/kg porcine motilin induced a premature antral phase III of antral origin. But perfusion into stomach with UDCA resulted in shorter MMC cycle duration, longer duration of phase III of duodenal origin, which were followed with shorter cycle duration and duration of antral phase III.

Conclusion: In fasted rats, MMC could originate from antrum and duodenum respectively. The characteristics of MMC of different origins may contribute to the large variations within subjects. The mechanisms of different origins of phase III may be different. Porcine motilin and UDCA could affect MMC of different origins of the gastrointestinal tract in fasted state, respectively.

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Figures

Figure 1
Figure 1
MMC cycle duration of all subjects following phase III. ○, antral origin; ▲, duodenal origin; Solid line: antral mean MMC cycle duration (746.3) ; Dotted line: duodenal mean MMC cycle duration (667.0).
Figure 2
Figure 2
Effects of porcine motilin on the interdigestive gastrointestinal myoelectric activity in one case.
Figure 3
Figure 3
Effects of UDCA on the interdigestive gastrointestinal myoelectrical activity in one case.
See this image and copyright information in PMC

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