Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Sep;64(3):304-7.
doi: 10.1111/j.1399-0039.2004.00274.x.

Description of a novel HLA-DRB1 allele found in a candidate for bone marrow transplantation

V Mas  1 , M T Arias, V Fabregat, B Nomdedeu, C Serrapagès, J Vives, J Martorell, E Carreras, M G Ercilla
Affiliations

Description of a novel HLA-DRB1 allele found in a candidate for bone marrow transplantation

V Mas et al. Tissue Antigens. 2004 Sep.

Abstract

We report the identification of a new DRB1* allele in a Spanish Caucasoid family during a search for a histocompatible bone marrow donor. This novel allele, designated as DRB1*1145, differs from DRB1*1123 in one nucleotide at position 199 in exon 2 (A replacing T), leading to one amino acid change from phenylalanine (Phe) to isoleucine (Ile) at codon 67. The propositus's father had identical class II alleles but showed a minor mismatch at locus B (B*4403 by B*4402) and a C-locus mismatch (Cw*1502 by Cw*0501). We discuss the criteria of selecting a non-related bone marrow donor with a minor mismatch on the DRB1* allele or the related father having a minor mismatch at B locus and a C-locus mismatch.

PubMed Disclaimer