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. 2004 Aug 13;572(1-3):172-6.
doi: 10.1016/j.febslet.2004.06.096.

P-Rex2, a new guanine-nucleotide exchange factor for Rac

Sarah Donald  1 , Kirsti Hill, Charlotte Lecureuil, Romain Barnouin, Sonja Krugmann, W John Coadwell, Simon R Andrews, Simon A Walker, Phillip T Hawkins, Len R Stephens, Heidi C E Welch
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Free article

P-Rex2, a new guanine-nucleotide exchange factor for Rac

Sarah Donald et al. FEBS Lett. .
Free article

Abstract

We have identified a new guanine-nucleotide exchange factor, P-Rex2, and cloned it from human skeletal muscle and brain libraries. It has widespread tissue distribution but is not expressed in neutrophils. P-Rex2 is a 183 kDa protein that activates the small GTPase Rac and is regulated by phosphatidylinositol (3,4,5)-trisphosphate and the beta gamma subunits of heterotrimeric G proteins in vitro and in vivo. P-Rex2 has structure, activity and regulatory properties similar to P-Rex1 but has divergent tissue distribution, as P-Rex1 is mainly expressed in neutrophils. Together, they form an enzyme family capable of mediating Rac signalling downstream of G protein-coupled receptors and phosphoinositide 3-kinase.

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