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Comment
. 2004 Aug;21(2):133-4.
doi: 10.1016/j.immuni.2004.07.015.

Another fork in the road: Foxo3a regulates NF-kappaB activation

Helen Su  1 , Nicolas Bidere, Michael Lenardo
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Another fork in the road: Foxo3a regulates NF-kappaB activation

Helen Su et al. Immunity. 2004 Aug.
Free article

Abstract

Previous studies have implicated the transcription factor FoxO3a in apoptosis induction. Thus, it comes as a surprise in this issue of Immunity that lymphoproliferative disease in Foxo3a-deficient mice may be due to T cell hyperactivity instead of cell death defects. Lin and colleagues provide important new evidence that disease development is associated with NF-kappaB hyperactivation in T cells.

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