Review
doi: 10.1016/j.idc.2004.04.010.
Macrolides and ketolides: azithromycin, clarithromycin, telithromycin
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- PMID: 15308279
- DOI: 10.1016/j.idc.2004.04.010
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Review
Macrolides and ketolides: azithromycin, clarithromycin, telithromycin
Infect Dis Clin North Am.
2004 Sep.
Abstract
The advanced macrolides, azithromycin and clarithromycin, and the ketolide telithromycin are structural analogues of erythromycin. They have several distinct advantages when compared with erythromycin including enhanced spectrum of activity, more favorable pharmacokinetics and pharmacodynamics, once daily administration, and improved tolerability. This article reviews the pharmacokinetics, antimicrobial activity, clinical use, and adverse effects of these antimicrobial agents.
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