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Case Reports
. 2004 Sep;90(9):e57.
doi: 10.1136/hrt.2004.039214.

Thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome associated with clopidogrel: report of two new cases

F Andersohn  1 , F G Hagmann, E Garbe
Affiliations
Case Reports

Thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome associated with clopidogrel: report of two new cases

F Andersohn et al. Heart. 2004 Sep.

Abstract

Clopidogrel has been reported to be safe and effective in reducing vascular events. Nevertheless, there is growing evidence that clopidogrel may cause thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome (TTP/HUS). This association has been debated, since in several cases alternative causes could not be excluded. Two new cases of TTP/HUS associated with clopidogrel are reported here. After discontinuation of clopidogrel and treatment with plasma exchange, both patients had a complete and sustained recovery from TTP/HUS. These cases corroborate previous observations that clopidogrel may indeed be a rare cause of TTP/HUS.

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Figures

Figure 1
Figure 1
Case 1. Medication and course of platelet, haemoglobin, and lactate dehydrogenase (LDH) concentrations.
Figure 2
Figure 2
Case 2. Medication and course of platelets, haemoglobin, and LDH. ASA, acetylsalicylic acid (aspirin).
See this image and copyright information in PMC

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