doi: 10.1021/ar030051b.
Asymmetric catalysis with "planar-chiral" derivatives of 4-(dimethylamino)pyridine
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- PMID: 15311953
- DOI: 10.1021/ar030051b
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Asymmetric catalysis with "planar-chiral" derivatives of 4-(dimethylamino)pyridine
Acc Chem Res.
2004 Aug.
Abstract
Whereas chiral Lewis acid catalysis has been intensively investigated, chiral Lewis base (nucleophilic) catalysis has been comparatively neglected. We have developed "planar-chiral" derivatives of 4-(dimethylamino)pyridine (DMAP), a highly versatile nucleophilic catalyst, that are effective in a diverse array of processes, including the Staudinger synthesis of beta-lactams, the acylation of silyl ketene acetals, and the kinetic resolution of amines.
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