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. 2004 Aug;37(8):542-7.
doi: 10.1021/ar030051b.

Asymmetric catalysis with "planar-chiral" derivatives of 4-(dimethylamino)pyridine

Gregory C Fu  1
Affiliations

Asymmetric catalysis with "planar-chiral" derivatives of 4-(dimethylamino)pyridine

Gregory C Fu. Acc Chem Res. 2004 Aug.

Abstract

Whereas chiral Lewis acid catalysis has been intensively investigated, chiral Lewis base (nucleophilic) catalysis has been comparatively neglected. We have developed "planar-chiral" derivatives of 4-(dimethylamino)pyridine (DMAP), a highly versatile nucleophilic catalyst, that are effective in a diverse array of processes, including the Staudinger synthesis of beta-lactams, the acylation of silyl ketene acetals, and the kinetic resolution of amines.

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