doi: 10.1021/ar0300524.
Theory of asymmetric organocatalysis of Aldol and related reactions: rationalizations and predictions
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- PMID: 15311955
- DOI: 10.1021/ar0300524
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Theory of asymmetric organocatalysis of Aldol and related reactions: rationalizations and predictions
Acc Chem Res.
2004 Aug.
Abstract
Computational studies have led to models to understand some classic and contemporary asymmetric reactions involving organocatalysts. The Hajos-Parrish-Eder-Sauer-Wiechert reaction and intermolecular aldol reactions as well as Mannich reactions and oxyaminations catalyzed by proline and other amino acids, and Diels-Alder reactions catalyzed by MacMillan's chiral amine organocatalysts have been studied with density functional theory. Quantitative predictions for several new catalysts and reactions are provided.
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