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. 2004 Aug;8(4):R248-50.
doi: 10.1186/cc2889. Epub 2004 Jun 15.

Marked elevations in N-terminal brain natriuretic peptide levels in septic shock

Gerald Chua  1 , Lee Kang-Hoe
Affiliations

Marked elevations in N-terminal brain natriuretic peptide levels in septic shock

Gerald Chua et al. Crit Care. 2004 Aug.

Abstract

Introduction: N-terminal pro brain natriuretic peptide (NT-proBNP) is a cardiac biomarker that has recently shown to be of diagnostic value in a diagnosis of decompensated heart failure, acute coronary syndromes and other conditions resulting in myocardial stretch. We sought to study whether sepsis-induced myocardial dilation would result in an elevation of NT-proBNP.

Method: Serum NT-proBNP measurements were made in six consecutive patients with septic shock within 6 hours of admission to the intensive care unit.

Results: Markedly elevated levels of NT-proBNP were found in all six patients.

Conclusions: NT-proBNP levels can be markedly elevated in critically ill patients presenting with septic shock. An elevated NT-proBNP level in a critically ill patient is not specific for decompensated heart failure.

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References

    1. Clerorico A, Iervasi G, Mariani G. Pathophysiologic relevance of measuring the plasma levels of cardiac natriuretic peptide hormones in humans. Horm Metab Res. 1999;31:487–498. - PubMed
    1. Maisel A, Krishnaswamy P, Nowak R. Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J Med. 2002;347:161–167. doi: 10.1056/NEJMoa020233. - DOI - PubMed
    1. de Lemos J, McGuire D, Drazner M. B-type natriuretic peptide in cardiovascular disease. Lancet. 2003;362:316–322. doi: 10.1016/S0140-6736(03)13976-1. - DOI - PubMed
    1. Witthaut R, Busch C, Fraunberger P, Walli A, Seidel D, Piltz G, Stuttmann R, Speichermann N, Verner L, Werdan K. Plasma atrial natriuretic peptide and brain natriuretic peptide are increased in septic shock: impact of interleukin-6 and sepsis-associated left ventricular dusfunction. Intensive Care Med. 2003;29:1696–1702. doi: 10.1007/s00134-003-1910-0. - DOI - PubMed
    1. Charpentier J, Luyt C, Fulla Y, Vinsonneau C, Cariou A, Grabar S, Dhainaut JF, Mira JP, Chiche JD. Brain natriuretic peptide: a marker of myocardial dysfunction and prognosis during severe sepsis. Crit Care Med. 2004;32:660–665. doi: 10.1097/01.CCM.0000114827.93410.D8. - DOI - PubMed

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