Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2004 Nov;45(6):787-97.
doi: 10.1016/j.neuint.2004.03.009.

The NOS/sGC pathway in the rat central nervous system: a microdialysis overview

Olimpia Pepicelli  1 , Maurizio Raiteri, Ernesto Fedele
Affiliations
Review

The NOS/sGC pathway in the rat central nervous system: a microdialysis overview

Olimpia Pepicelli et al. Neurochem Int. 2004 Nov.

Abstract

It is now well established that nitric oxide is involved in a variety of physiopathological processes in the central nervous system, which mainly result from the interaction of this gaseous molecule with the heme group of soluble guanylyl cyclase and the elevation of intracellular cGMP in target neurons. During the last decade, several studies have monitored extracellular cGMP, by means of intracerebral microdialysis, to investigate in vivo the functioning and modulation of this neurochemical pathway under different experimental conditions and in various brain regions. In this review, we summarise some of the most relevant results obtained in this research field.

PubMed Disclaimer

Publication types

LinkOut - more resources