Design of beta-sheet systems for understanding the thermodynamics and kinetics of protein folding
- PMID: 15313241
- DOI: 10.1016/j.sbi.2004.06.001
Design of beta-sheet systems for understanding the thermodynamics and kinetics of protein folding
Abstract
Peptide beta-sheet systems have emerged as context-independent models for probing secondary structure propensities, the nature and magnitude of stabilizing weak interactions, and aspects of cooperativity both parallel and perpendicular to the strand direction. These systems have allowed fundamental advances in understanding non-covalent interactions relevant to both chemical and biological systems, and in describing the protein folding energy landscape.
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