Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Feb;89(2):507-11.
doi: 10.1172/JCI115613.

Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty

A Jawien  1 , D F Bowen-Pope, V Lindner, S M Schwartz, A W Clowes
Affiliations

Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty

A Jawien et al. J Clin Invest. 1992 Feb.

Abstract

Platelet-derived growth factor (PDGF) is a mitogen and chemoattractant for vascular smooth muscle cells (SMC) in vitro, but its activities in vivo remain largely undefined. We infused recombinant PDGF-BB (0.01-0.30 mg/kg per d i.v.) into rats subjected to carotid injury. PDGF-BB produced a small increase (two- to threefold) in medial SMC proliferation. More importantly, PDGF-BB greatly increased (20-fold) the intimal thickening and the migration of SMC from the media to the intima during the first 7 d after injury. These data provide support for the hypothesis that PDGF, and perhaps other platelet factors, might play an important role in the movement of mesenchymal cells into zones of injury undergoing repair.

PubMed Disclaimer

References

    1. Science. 1991 Sep 6;253(5024):1129-32 - PubMed
    1. J Clin Invest. 1982 Apr;69(4):1046-9 - PubMed
    1. J Clin Invest. 1990 Mar;85(3):916-20 - PubMed
    1. Arteriosclerosis. 1990 Nov-Dec;10(6):1082-7 - PubMed
    1. J Biol Chem. 1989 May 25;264(15):8771-8 - PubMed

Publication types

Substances