Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2004 Nov;36(11):2120-4.
doi: 10.1016/j.biocel.2003.11.008.

Signal transducer and activator of transcription 5 (STAT5)

Miranda Buitenhuis  1 , Paul J Coffer, Leo Koenderman
Affiliations
Review

Signal transducer and activator of transcription 5 (STAT5)

Miranda Buitenhuis et al. Int J Biochem Cell Biol. 2004 Nov.

Abstract

Signal transducer and activator of transcription 5 (STAT5) activity is induced by a plethora of cytokines and growth factors resulting in transcriptional activation of specific target genes. STAT5 plays an important role in a variety of cellular processes, including proliferation, differentiation, and apoptosis. Aberrant regulation of STAT5 has been observed in solid tumors as well as in patients with either chronic or acute myeloid leukemia. Kinase inhibitors are currently being developed to negatively regulate STAT5 activity for clinical purposes.

PubMed Disclaimer

MeSH terms

LinkOut - more resources