doi: 10.1021/ja046574b.
An intramolecular Diels-Alder approach to the eunicelins: enantioselective total synthesis of ophirin B
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- PMID: 15315437
- DOI: 10.1021/ja046574b
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An intramolecular Diels-Alder approach to the eunicelins: enantioselective total synthesis of ophirin B
J Am Chem Soc.
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Abstract
The enantioselective synthesis of the eunicellin ophirin B has been completed. A ring-closing metathesis provides efficient access to the oxonene ring, and a highly diastereoselective intramolecular Diels-Alder reaction results in the formation of the hydrobenzofuran portion of the molecule.
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