An intramolecular Diels-Alder approach to the eunicelins: enantioselective total synthesis of ophirin B

Abstract

The enantioselective synthesis of the eunicellin ophirin B has been completed. A ring-closing metathesis provides efficient access to the oxonene ring, and a highly diastereoselective intramolecular Diels-Alder reaction results in the formation of the hydrobenzofuran portion of the molecule.