[Amlodipine: pharmacokinetic and pharmacodynamic profile of a calcium antagonist with prolonged effect]
- PMID: 1531545
[Amlodipine: pharmacokinetic and pharmacodynamic profile of a calcium antagonist with prolonged effect]
Abstract
Amlodipine is a new calcium antagonist of the 1.4-dihydropyridine group for treatment of hypertension and angina pectoris. Amlodipine is distinct from other calcium antagonists by its pharmacokinetic profile: slower onset of action with less acute vasodilatation associated side effects and a sustained antihypertensive and anti-anginal efficacy over 24 hours.