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. 2004 Aug 20;118(4):431-8.
doi: 10.1016/j.cell.2004.08.006.

AID is required for c-myc/IgH chromosome translocations in vivo

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Free article

AID is required for c-myc/IgH chromosome translocations in vivo

Almudena R Ramiro et al. Cell. .
Free article

Abstract

Chromosome translocations between c-myc and immunoglobulin (Ig) are associated with Burkitt's lymphoma in humans and with pristane- and IL6-induced plasmacytomas in mice. These translocations frequently involve Ig switch regions, suggesting that they might be the result of aberrant Ig class switch recombination (CSR). However, a direct link between CSR and chromosome translocations has not been established. We have examined c-myc/IgH translocations in IL6 transgenic mice that are mutant for activation induced cytidine deaminase (AID), the enzyme that initiates CSR. Here we report that AID is essential for the c-myc/IgH chromosome translocations induced by IL6.

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