Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Sep 9;22(27-28):3789-96.
doi: 10.1016/j.vaccine.2004.02.046.

Most humoral non-responders to hepatitis B vaccines develop HBV-specific cellular immune responses

L Jarrosson  1 , M N Kolopp-Sarda, P Aguilar, M C Béné, M L Lepori, M C Vignaud, G C Faure, C Kohler
Affiliations

Most humoral non-responders to hepatitis B vaccines develop HBV-specific cellular immune responses

L Jarrosson et al. Vaccine. .

Abstract

About 10% of health care professionals vaccinated against hepatitis B virus (HBV) fail to develop protective antibodies. We tested the capacity of peripheral blood lymphocytes from 121 health care professionals, including 76 non-responders, to proliferate to four HBV vaccines, examined the proliferating cells' subset, production of IFN-gamma, IL-4 and IL-10, and for 22 subjects, the cytokine production genotype. Specific proliferative responses to at least one HBV antigen were noted in 75% humoral non-responders. These cells differed from the CD4+ strongly proliferating cells of responders. Non-responders frequently displayed a genotype of high TGF-beta and intermediate IL-10 secretion. Most humoral non-responders to HBV thus develop specific cellular immune responses, eventually liable to protect them against viral infection.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources