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Review
. 2004 Aug;61(16):2010-9.
doi: 10.1007/s00018-004-4050-y.

Phosphinic peptides as zinc metalloproteinase inhibitors

V Dive  1 , D Georgiadis, M Matziari, A Makaritis, F Beau, P Cuniasse, A Yiotakis
Affiliations
Review

Phosphinic peptides as zinc metalloproteinase inhibitors

V Dive et al. Cell Mol Life Sci. 2004 Aug.

Abstract

Solid-phase synthesis of phosphinic peptides was introduced 10 years ago. A major application of this chemistry has been the development of potent synthetic inhibitors of zinc metalloproteases. Specific properties of the inhibitors produced in recent years are reviewed, supporting the notion that phosphinic pseudo-peptides are useful tools for studying the structural and functional biology of zinc proteases.

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