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. 1992 Mar 1;89(5):1795-8.
doi: 10.1073/pnas.89.5.1795.

The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression

J A DeCaprio  1 , Y Furukawa, F Ajchenbaum, J D Griffin, D M Livingston
Affiliations

The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression

J A DeCaprio et al. Proc Natl Acad Sci U S A. .

Abstract

The retinoblastoma-susceptibility gene product (RB) undergoes cell cycle-dependent phosphorylation and dephosphorylation. We characterized RB phosphorylation after mitogenic stimulation of primary human T lymphocytes, initially arrested in the G0 state. RB is phosphorylated in at least three steps when T cells are driven into the cell cycle. The first event occurs during mid G1 phase, the second during S phase, and the third in G2/M. Tryptic phosphopeptide mapping indicates that the different phosphorylation events occur, at least in part, on different residues in RB. Given the known relationship of the RB phosphorylation state to function, it is possible that RB regulates growth at multiple points in the cell cycle.

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References

    1. Biochem Biophys Res Commun. 1989 Oct 16;164(1):580-6 - PubMed
    1. Oncogene. 1989 Jun;4(6):807-12 - PubMed
    1. Cell. 1989 Sep 22;58(6):1085-95 - PubMed
    1. Cell. 1989 Sep 22;58(6):1193-8 - PubMed
    1. Science. 1989 Jan 20;243(4889):355-61 - PubMed

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