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. 2004 Sep;5(9):855-9.
doi: 10.1038/sj.embor.7400220.

Molecular mechanisms in signal transduction and cancer

Johannes L Bos  1 , Boudewijn M T Burgering
Affiliations

Molecular mechanisms in signal transduction and cancer

Johannes L Bos et al. EMBO Rep. 2004 Sep.

Abstract

Meeting on Oncogenes & Growth Control

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Figures

Figure 1
Figure 1
A schematic version of the hedgehog signalling pathway. Hedgehog (Hh), when bound to its receptor patched (Ptc), will relieve the inhibition of Ptc on smoothend (Smo). Activated Smo in turn will activate members of the Gli transcription factor family.
Figure 2
Figure 2
The structure of B-Raf in the vicinity of the catalytic site. Mutation of Val 599 to Glu activates B-Raf by 500-fold. In the wild-type protein, the inactive conformation of the activation segment (red) is stabilized by buried hydrophobic interactions between the aliphatic side chain of Val 599 of the activation segment and Phe 467 of the P-loop. Conversion of the activation segment to the active conformation (green) requires exposure of Val 599. Val 599 therefore stabilizes the inactive conformation relative to the active state. By contrast, a Glu at position 599 stabilizes the active conformation after it is solvent exposed by interacting with Lys 506 of the αC-helix and destabilizes the inactive conformation by forming unfavourable interactions with Phe 467. The position of the Bayer–Onyx compound (BAY43-9006) that stabilizes the inactive conformation is indicated. For more details, see Wan et al, 2004.
Figure 3
Figure 3
LKB1 a master regulator. LKB1 has been shown to act as a T-loop kinase for several kinases (Lizcano et al, 2004) including the partitioning-defective kinases (PARs) and AMPK. The work discussed by H. Clevers suggests that LKB1 through PARs can act to regulate cell polarity (Baas et al, 2004). D. Alessi showed that LKB1 acts to regulate AMPK, a kinase that is involved in sensing the cellular ratio of AMP/ATP (Hawley et al, 2003).
None
The EMBL/Salk/EMBO Conference on 'Oncogenes & Growth Control' was held at the EMBL in Heidelberg, Germany, between 17 and 20 April 2004, and was organized by M. Bienz, G. Evan, C. Marshall, A. Nebreda and R. Treisman
None
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