Review
doi: 10.2174/1568026043387999.
The application of x-ray, NMR, and molecular modeling in the design of MMP inhibitors
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- PMID: 15320728
- DOI: 10.2174/1568026043387999
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Review
The application of x-ray, NMR, and molecular modeling in the design of MMP inhibitors
Curr Top Med Chem.
2004.
Abstract
The following review discusses the successful application of X-ray, NMR, and molecular modeling in the design of potent and selective inhibitors of matrix metalloproteinases (MMPs) and TNFalpha-converting enzyme (TACE) from Wyeth. The importance of protein and ligand mobility as it impacts structure-based design is also discussed. The MMPs are an active target for a variety of diseases, including cancer and arthritis.
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