Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Mar;174(6):1948-55.
doi: 10.1128/jb.174.6.1948-1955.1992.

Lambda placMu insertions in genes of the leucine regulon: extension of the regulon to genes not regulated by leucine

R Lin  1 , R D'Ari, E B Newman
Affiliations

Lambda placMu insertions in genes of the leucine regulon: extension of the regulon to genes not regulated by leucine

R Lin et al. J Bacteriol. 1992 Mar.

Abstract

The leucine regulon coordinates the expression of several Escherichia coli genes according to the presence of exogenous leucine, which interacts with the lrp gene product, Lrp. We isolated and characterized 22 strains with lambda placMu insertions in Lrp-regulated genes. Lrp and leucine influenced gene expression in a surprising variety of ways. We identified two genes that are regulated by Lrp and not affected by L-leucine. We therefore rename this the leucine-lrp regulon. Genes coding for glycine cleavage and leucine biosynthesis enzymes have been identified as members of the leucine-lrp regulon. We suggest that the lrp gene product activates genes needed for growth in minimal medium, and we show that the gene is repressed by its own product and is highly repressed during growth in rich medium.

PubMed Disclaimer

References

    1. Cell. 1987 Jul 31;50(3):495-508 - PubMed
    1. Gene. 1986;44(2-3):219-26 - PubMed
    1. Microbiol Rev. 1987 Sep;51(3):301-19 - PubMed
    1. EMBO J. 1988 Dec 20;7(13):4389-95 - PubMed
    1. J Mol Biol. 1981 Jul 15;149(4):579-97 - PubMed

Publication types

LinkOut - more resources