Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Sep;89(5):F412-6.
doi: 10.1136/adc.2002.016717.

Pulmonary antioxidant concentrations and oxidative damage in ventilated premature babies

K J Collard  1 , S Godeck, J E Holley, M W Quinn
Affiliations

Pulmonary antioxidant concentrations and oxidative damage in ventilated premature babies

K J Collard et al. Arch Dis Child Fetal Neonatal Ed. 2004 Sep.

Abstract

Objective: To determine the relation between lipid peroxidation and the antioxidants ascorbate, urate, and glutathione in epithelial lining fluid in ventilated premature babies, and to relate the biochemical findings to clinical outcome.

Design: A cohort study conducted between January 1999 and June 2001.

Setting: A NHS neonatal intensive care unit.

Patients: An opportunity sample of 43 ventilated babies of less than 32 weeks gestation.

Main outcome measures: The duration of supplementary oxygen according to the definition of bronchopulmonary dysplasia (BPD; oxygen dependency at 36 weeks gestational age).

Methods: Epithelial lining fluid was sampled by bronchoalveolar lavage. Ascorbate, urate, glutathione, and malondialdehyde (a marker of lipid peroxidation) were measured.

Results: Babies who developed BPD had significantly lower initial glutathione concentrations (mean (SEM) 1.89 (0.62) v 10.76 (2.79) microM; p = 0.043) and higher malondialdehyde concentrations (mean (SEM) 1.3 (0.31) v 0.345 (0.09) microM; p < 0.05) in the epithelial lining fluid than those who were not oxygen dependent. These variables were poor predictors of the development of BPD. Gestational age, endotracheal infection, and septicaemia had good predictive power. The level of oxidative damage was associated with the presence of endotracheal infection/septicaemia rather than inspired oxygen concentration.

Conclusions: Endotracheal infection, septicaemia, and gestational age, rather than antioxidant concentrations, are the most powerful predictors of the development of BPD.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Concentrations of urate, ascorbate, and malondialdehyde in the first week of life in the total number of babies (n  =  8) who were ventilated for more than a week. Malondialdehyde concentration was measured in only five of these. Data are consequently expressed as mean (SEM) for eight babies for urate and ascorbate, and mean (SEM) for five babies for malondialdehyde.
See this image and copyright information in PMC

References

    1. Eur Respir J. 1997 Jun;10(6):1392-400 - PubMed
    1. Crit Care Med. 1996 Jan;24(1):29-37 - PubMed
    1. Clin Chim Acta. 1997 Sep 8;265(1):113-9 - PubMed
    1. Pediatrics. 1997 Dec;100(6):987-93 - PubMed
    1. Acta Paediatr. 1997 Dec;86(12):1277-82 - PubMed

Publication types

MeSH terms