Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2004 Oct;449(1):1-15.
doi: 10.1007/s00424-004-1296-z.

Human pulmonary vascular responses to hypoxia and hypercapnia

K L Dorrington  1 , N P Talbot
Affiliations
Review

Human pulmonary vascular responses to hypoxia and hypercapnia

K L Dorrington et al. Pflugers Arch. 2004 Oct.

Abstract

The ability of alveolar gas composition to influence pulmonary vascular tone has been appreciated for over 50 years. In particular, it has been proposed that both O2 and CO2 could play a role in the matching of perfusion to ventilation within the lung, improving the overall efficiency of gas exchange. A wide variety of experimental approaches has been used to investigate pulmonary vascular effects of the respiratory gases in a range of mammalian species. In this article, we review experiments performed in healthy humans, identify particular difficulties in the interpretation of such experiments, and discuss possible approaches to future study.

PubMed Disclaimer

References

    1. J Appl Physiol (1985). 1987 Aug;63(2):521-30 - PubMed
    1. Am J Respir Crit Care Med. 1999 Aug;160(2):473-9 - PubMed
    1. New Horiz. 1996 Feb;4(1):99-106 - PubMed
    1. Respir Physiol. 1995 Jun;100(3):271-81 - PubMed
    1. J Thorac Surg. 1950 Jan;19(1):80-116 - PubMed

Publication types

LinkOut - more resources