Review
The Maillard reaction inhibitors and their biological and therapeutic significance
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- PMID: 15323184
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Review
The Maillard reaction inhibitors and their biological and therapeutic significance
Ann Univ Mariae Curie Sklodowska Med.
2003.
Abstract
The formation of AGE crosslinks as a result of the Maillard reaction is reduced by several drugs (aminoguanidine, OPB-9195, tenilsetam, aspirin), substances of natural origin (carnosine, homocarnosine) and antioxidants. These compounds are the Maillard reaction inhibitors, but do not seem to break AGE-derived protein crosslinks, which have already formed and therefore will not be effective in patients with a long history of the disease. The first in a new class of compounds that have been shown the ability to chemically reverse the Maillard reaction is PTB. This compound breaks the carbon-carbon bond between two carbonyls of glucose-derived protein crosslinks.
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