Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Mar;30(3):729-31.
doi: 10.1128/jcm.30.3.729-731.1992.

Phenotypic profile and functional characteristics of human gamma and delta T cells during acute toxoplasmosis

P De Paoli  1 , G Basaglia, D Gennari, M Crovatto, M L Modolo, G Santini
Affiliations

Phenotypic profile and functional characteristics of human gamma and delta T cells during acute toxoplasmosis

P De Paoli et al. J Clin Microbiol. 1992 Mar.

Abstract

Gamma and delta (gamma delta) T-cell receptor lymphocytes are increased during acute toxoplasmosis. These cells are BB3+ CD45RO+ CD8-. Purified gamma delta T cells failed to proliferate in response to Toxoplasma gondii antigen (stimulation index, 1.4 +/- 0.6) but were responsive to phytohemagglutinin stimulation (stimulation index, 20.8 +/- 1.9). Natural-killer-like cytotoxicity was strongly acquired only after in vitro culture of purified gamma delta T cells with recombinant interleukin 2 (40% +/- 7% specific lysis). Our data show that gamma delta T-cell receptor T cells with a peculiar phenotype are increased during human acute T. gondii infection.

PubMed Disclaimer

References

    1. J Clin Invest. 1990 Jun;85(6):1879-86 - PubMed
    1. J Immunol. 1985 Dec;135(6):4160-3 - PubMed
    1. N Engl J Med. 1990 Jan 11;322(2):73-6 - PubMed
    1. J Exp Med. 1990 May 1;171(5):1833-8 - PubMed
    1. Immunol Today. 1990 Feb;11(2):40-3 - PubMed

Substances