doi: 10.1111/j.1399-0004.2004.00293.x.
Genetic analysis of lethal congenital malformations causing perinatal mortality at Nizwa Hospital, Oman
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- PMID: 15324324
- DOI: 10.1111/j.1399-0004.2004.00293.x
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Genetic analysis of lethal congenital malformations causing perinatal mortality at Nizwa Hospital, Oman
Clin Genet.
2004 Sep.
Abstract
An analysis of lethal congenital malformations (LCM) - which contributed to perinatal mortality at Nizwa Hospital, Oman - is presented for a 10-year period from January 1993 through December 2002. Single gene, chromosomal or multifactorial inheritance accounted for 86.1% of the cases. LCM-related perinatal deaths were higher in Omani, compared to those in non-Omani births (p < 0.001). This could possibly be attributed to high consanguinity, low female literacy and high fertility rates in the Omani population. Forty per cent of LCM-related perinatal deaths in the study had potential options for prevention. Integration of a community-based genetic service into the existing health-care delivery system is suggested.
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