Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Jul;10(7):1250-7.
doi: 10.3201/eid1007.030612.

Fluoroquinolone and other antimicrobial resistance in invasive pneumococci, Hong Kong, 1995-2001

Pak-Leung Ho  1 , Tak-Lun Que, Susan S Chiu, Raymond W H Yung, Tak-Keung Ng, Dominic N C Tsang, Wing-Hong Seto, Yu-Lung Lau
Affiliations

Fluoroquinolone and other antimicrobial resistance in invasive pneumococci, Hong Kong, 1995-2001

Pak-Leung Ho et al. Emerg Infect Dis. 2004 Jul.

Abstract

We determined the susceptibilities of 265 invasive isolates of pneumococci obtained during 1995 to 2001 in Hong Kong to 11 antimicrobial agents and their serotypes. Overall, 62.6% isolates were susceptible to penicillin, 20% were intermediately resistant, and 17.4% were resistant. The overall prevalence of levofloxacin resistance (MIC > or = 8 microg/mL) was 3.8% but increased to 15.2% among the penicillin-resistant isolates. All levofloxacin-resistant isolates were clonally related; had reduced susceptibility to penicillin, cefotaxime, and clarithromycin; and were derived from adults > or = 50 years of age. Of the penicillin-nonsusceptible pneumococci, 90% from children < or = 5 years of age and 54.8% from persons of all ages were of serotypes that are included in the 7-valent pneumococcal conjugate vaccine; 93.5% from children < or = 5 years of age and 93% from persons of all ages were of serotypes that are included in the 23-valent polysaccharide vaccine.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Susceptibility rates for 265 invasive Streptococcus pneumoniae in Hong Kong by year, 1995–2001.
Figure 2
Figure 2
HinfI fingerprints of the pbp genes. A, pbp2b profiles. Lanes 1, marker; 2, Spain23F-1 clone (SP264, ATCC 700669); 3, a ciprofloxacin-resistant, levofloxacin-susceptible strain S1D3; 4, Spain6B clone (GM17, ATCC 700670); lane 5–14, 10 isolates of levofloxacin resistant pneumococci (S3F7, S2H9, S1B7, S1B9, S1D5, S2D6, S1D2, S2F3, 186G1, and 216D2, respectively); B, pbp2x profiles. The lanes were arranged in the same sequence as in A.
See this image and copyright information in PMC

References

    1. Ho PL, Cheng VCC. Epidemiology and mechanisms of resistance. In: Ronald AR, Low DE, editors. Milestones in drug therapy: fluoroquinolone antibiotics. Berlin: Birkhauser; 2003. p. 49–72.
    1. Chen DK, McGeer A, de Azavedo JC, Low DE. Decreased susceptibility of Streptococcus pneumoniae to fluoroquinolones in Canada. Canadian Bacterial Surveillance Network. N Engl J Med. 1999;341:233–9. 10.1056/NEJM199907223410403 - DOI - PubMed
    1. Ho PL, Que TL, Tsang DN, Ng TK, Chow KH, Seto WH. Emergence of fluoroquinolone resistance among multiply resistant strains of Streptococcus pneumoniae in Hong Kong. Antimicrob Agents Chemother. 1999;43:1310–3. - PMC - PubMed
    1. Ho PL, Yung RW, Tsang DN, Que TL, Ho M, Seto WH, et al. Increasing resistance of Streptococcus pneumoniae to fluoroquinolones: results of a Hong Kong multicentre study in 2000. J Antimicrob Chemother. 2001;48:659–65. 10.1093/jac/48.5.659 - DOI - PubMed
    1. National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial susceptibility testing: eleventh informational supplement. 2001. M100-S11. Wayne (PA): The Committee; 2001.

Publication types

LinkOut - more resources