Comparative Study
doi: 10.1016/j.bmcl.2004.07.009.
Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: metabolism-directed optimization studies towards orally bioavailable derivatives
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- PMID: 15324875
- DOI: 10.1016/j.bmcl.2004.07.009
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Comparative Study
Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: metabolism-directed optimization studies towards orally bioavailable derivatives
Bioorg Med Chem Lett.
.
Abstract
The synthesis and optimization of pharmacokinetic parameters of structurally novel small PDE7 inhibitors is discussed.
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