Comparative Study
doi: 10.1016/j.bmcl.2004.07.011.
Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1
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- PMID: 15324876
- DOI: 10.1016/j.bmcl.2004.07.011
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Comparative Study
Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1
Bioorg Med Chem Lett.
.
Abstract
The synthesis and SAR studies of spiroquinazolinones as novel PDE7 inhibitors are discussed. The best compounds from the series displayed nanomolar inhibitory affinity and were selective versus other PDE isoenzymes.
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